DAMASCUS, Syria (AP) -- A massive car bomb exploded near Syria's ruling party headquarters in Damascus on Thursday, killing at least 53 people and scattering mangled bodies amid the smoldering wreckage.
Syrian state media put the toll at 53 with more than 200 wounded. However, anti-regime activists said 59 died, which would make this the deadliest attack in the capital since the Syrian uprising began nearly two years ago. In May, a double suicide bombing killed 55 people in Damascus.
Three straight days of mortar attacks on the center of Damascus after recent rebel advances in the suburbs marked the most sustained rebel challenge in the heart of President Bashar Assad's seat of power.
Within hours of the car bombing, two other bombs went off elsewhere in the city and a mortar attack struck the army's central command. Thirteen people were killed by the other two bombs, activists said.
While no group has claimed responsibility, the attacks suggest that rebel fighters who have gotten bogged down in their attempts to storm the capital are resorting to guerrilla tactics to loosen Assad's grip on the capital.
The day's deadliest attack struck a main street on the edge of central Mazraa neighborhood, near the headquarters of Assad's ruling Baath party and the Russian Embassy, as well as a mosque, a hospital and a school.
TV footage of the blast site showed firemen dousing a flaming car with hoses and lifeless and dismembered bodies blown into the grass of a nearby park. The state news service, SANA, published photos showing a large crater in the middle of the rubble-strewn street and charred cars holding blackened bodies.
Witnesses at the scene said a car exploded at a security checkpoint between the Russian Embassy and the central headquarters of Assad's ruling party.
"It was huge. Everything in the shop turned upside down," one local resident said. He said three of his employees were injured by flying glass that killed a young girl who was walking by when the blast hit.
"I pulled her inside the shop but she was almost gone. We couldn't save her. She was hit in the stomach and head," he said, speaking on condition of anonymity for fear of retribution for speaking with foreign media.
Ambulances rushed to the scene of the blast, which shattered windows and sent up a huge cloud of smoke visible throughout much of the city, witnesses said.
State TV called it a "terrorist" attack by a suicide bomber. The regime commonly refers to rebels fighting to overthrow Assad as terrorists.
The Britain-based activist group the Syrian Observatory for Human Rights said at least 59 people were killed, including 16 members of the security forces. The rest were civilians, it said.
There was no way to immediately reconcile the differing death tolls.
The bombing was one of the two deadliest in the Syrian capital since the uprising against Assad began 23 months ago. Fifty-five people were killed in the first, a double suicide bombing outside of an intelligence building in May, 2012.
The most extreme of Syria's rebel groups, Jabhat al-Nusra, claimed responsibility for that and other bombings that have struck targets associated with the regime but also killed civilians.
Such tactics have galvanized Assad's supporters and made many other Syrians distrustful of the rebel movement as a whole, most of whose fighting groups do not use such tactics.
The main opposition group, the Syrian National Coalition, condemned the blast without accusing a specific group of carrying it out. It did, however, suggest that the regime allowed foreign terrorist groups to operate in Syria.
"The terrorist Assad regime bears the most responsibility for all the crimes that happen in the homeland because it has opened the doors to those with different agendas to enter Syria and harm its stability so it can hide behind this and use it as an excuse to justify its crimes," the group said in a statement on its Facebook page.
Russia's state-owned RIA Novosti news agency quoted a Russian Embassy official as saying the Embassy building had been damaged in the blast but no one was hurt.
Among those wounded by flying glass near the blast was Nayef Hawatmeh, the leader of the Democratic Front for the Liberation of Palestine, a radical Damascus-based Palestinian group.
An official at his office, about 500 yards from the site of the explosion, said Hawatmeh was wounded in the hands and face from flying glass. He was taken to hospital and later released.
In a separate attack, Syrian state TV said mortar shells exploded near the Syrian Army General Command in central Damascus, causing no casualties. The station said the building was empty because it was under renovation.
The Observatory said two mortar rounds exploded near the building but did not report casualties.
On Wednesday, two mortar shells exploded next to a soccer stadium in Damascus, killing one player. The day before, two mortar shells blew up near one of Assad's three palaces in the city, causing only material damage.
Between the car bomb and the mortar attack near the army command, a security official reported another blast in the capital's northeastern Barzeh neighborhood. He had no other information and spoke on condition of anonymity because he was not authorized to brief the media.
The Observatory, which relies on a network of anti-regime activists inside Syria, said two car separate bombs had exploded near different security centers in Barzeh, followed by intense clashes between rebels and security forces. It said 13 people died in one of the Barzeh blasts, 10 of them security officers.
State media also reported that security forces in Damascus had arrested a second, would-be suicide bomber driving a car full of explosives near the site of the Mazraa bombing.
Damascus has so far mostly avoided the large-scale violence that has destroyed other Syrian cities, though deadly car bombings have targeted government buildings in the capital.
In May 2012, twin car bombs exploded outside a military intelligence building, killing 55 people in the deadliest attack against a regime target in the capital since the uprising began.
And in July, rebels detonated explosives inside a high-level crisis meeting in Damascus that killed four top regime officials, including Assad's brother-in-law and the defense minister.
Following that attack, rebel groups who have established footholds in suburbs of the capital pushed in, clashing with government forces for more than a week before being routed and pushed out.
Since then, government jets have heavily bombed rebel-held suburbs and rebels have managed only small incursions on the city's south and east sides.
In the southern town of Daraa, where Syria's uprising began nearly two years ago, the Observatory said 18 people were killed in an airstrike on a field hospital, included eight rebel fighters, three medics, one woman and one young girl.
A video posted online showed the bodies of dead and wounded people being loaded in to the backs of trucks and moved to another location. Some were bloody and had bandaged heads, while others were carried out on stretchers.
Syria's conflict began in March 2011 with political protests against the government and has since evolved into a civil war between Assad's regime and hundreds of rebel groups seeking to topple it. The U.N. says some 70,000 people have been killed in the conflict so far.
International diplomacy has failed to slow the fighting.
On Thursday, British Foreign Secretary William Hague said his message to Assad is that "it is time to go."
He said the senseless killing must be brought to an end through a political process.
He also called on Assad to respond to a dialogue offer made recently by Syrian opposition chief Mouaz al-Khatib.
"A political agreement on a transition is the way forward in Syria to bring to an end this terrible and unacceptable loss of life," he said.
Al-Khatib has said he is open to talks with the regime as a way of removing it from power. The government has refused.
Hubbard reported from Beirut. Associated Press writer Zeina Karam contributed reporting from Beirut.